Re: Brine shrimp toxicity

From: Jack Wekell (jwekell@comcast.net)
Date: Wed Feb 14 2007 - 09:24:33 PST

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    Dipak,
    Your question is way, way too broad! What exactly do you mean by "toxicity" and "pharmaceutical preparations"? Both these terms are so vast and diffuse that it would require quite literally quite a dissertation to answer it.  Are you requesting information about components in the brine shrimp that could be toxic, if so, toxic to humans, to test organisms, etc? Keep in mind that what might be toxic to a microbe may not be toxic to humans.

    In its simplest form, either a water extraction or some organic solvent extraction of the brine shrimp can be prepared and then injected into some suitable test animal, e.g., mouse. If the test animal shows some adverse or unusual symptoms, one might conclude the presence of some noxious component. Note that I say "might". Far more rigorous testing would be required to conclude that one way or the other.

    As to "pharmaceutical preparations", this covers a multitude of applications. A preparation meant for external use, e.g., ointments or localized injections, can be toxic if taken internally. Certainly, "Botox", would be a classic case of this!

    If you are looking to use some component of brine shrimp to be used in pharmaceutical preparations, and the component is heretofore not been reported or used for this application, be prepared for a very, very long path and journey--not to mention a very expensive one. If brine shrimp were to show some pharmaceutically active component, the time from discovery to actual implementation can be (optimistically) 10 to 15 years (and untold millions of dollars). If the brine shrimp component were already approved for pharmaceutical use, you might cut that development time significantly, perhaps (again optimistically) by half or a third. Here it would be demonstrating the safety of the process and final production of the component to the regulatory agency (here in the U.S., the Food and Drug Administration).


    John C. Wekell, Ph.D.

    Dipak Chaudhari wrote:

    Dear All,
    Good morning to you.
    Can anyone guide me where I can get procedure for conducting "brine shrimp toxicity" for pharmaceutical preparations? and how to interprete the rsults?
    Thanks
    Have a nice day!!
    Regards Dipak

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