Histamine Field Test - Chapter 2.

From: Schalk Alain (alain.schalk@cotecna.ch)
Date: Wed Feb 02 2005 - 01:01:38 PST

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    Dear James,

     

    I have put together the last 2 messages received from FDA specialists on the
    subject (yourself and Walter 's messages below attached) and I believe there
    is certainly something to reflect on... I fully understand you will not be
    able to answer on the FDA policy issues but I still feel important to share
    my views with you, your colleagues and the list members.

     

    If you ask me today about my need, as an inspection company, to purchase or
    detain such equipments I would say yes but without real interest as

    today the certification of the quality relies on some export certification
    schemes, quality assurance programs or state regulations which put
    practically at the same level the controls for histamine and
    Microbio.....and the microbio test requiring a long time to process there is
    sufficient time for the histamine tests to also take place in a
    laboratory....so no real need for quick tests as you imagine....

     

    But as suggested by Walter the establishment of a proper control mechanism
    along the supply chain would certainly call for numerous field tests

    to be duly recorded as part of a global quality insurance program involving
    spot controls at time of catch, on board handling, discharge, transit
    points, transport, process, export ....

     

    I believe we all know where the problem lies but we do not want to see
    it.... FDA and EU are pushing very hard for some new regulation to take
    place to force the suppliers (through the importers concern and liability)
    to build up, monitor, audit and promote a full quality program including,
    HACCP, Temperature abuse, mixture of catches reacting differently to
    histamine creation, clean process, and final export certification. And we
    must all admit that it just does not work but the consumer desperately need
    that confidence building process...And such needed program goes with
    traceability and field spot checks for sensible parameters such as
    histamine......

     

    The question is certainly to decide today on who and how such "valid control
    mechanism" could be set up ?

     

    Is it left to the industry to decide or would FDA be ready to discuss or
    even push one way or another for implementing same? Even if FDA does not

    wish or cannot be directly involved could we imagine them giving the
    blessing to an inspection firm having sufficient network and resources to
    prepare and audit the industry worldwide ? In such case the need for those
    quick checkers on histamine would be there and the main client/user would be
    the inspection company itself...being the arm of FDA and EU...

     

    According to my records, in the 1990 the National fishery Institute NFI
    started something similar by making a joint venture with a major

    consulting firm for offering HACCP training/audits in several
    countries....The scheme was voluntary and lacked strong support from state
    agencies...

    This kind of "Train the Trainers" program might be the solution but it
    should then be extended to cover on board handling, Histamine creation,
    HACCP/Temperature monitoring and final lab procedure...

    This is the direction the EU is taking by offering some funding to selected
    countries who accept to put their fishing dept at level regarding EU
    regulation (done through the use of consultants).

     

    Same potential partner could even set up control programs for checking sea
    food in restaurants, markets, cold stores etc.... under a different mandate
    in a specific country !

     

    Just some thoughts. I am not really sure they fit in your concern and even
    answer your question but I believe this is a concern to start working on if
    we want safe sea food in our plate for the years to come...

     

     

    Best regards.

     

    Alain Schalk

    Cotecna Inspection SA

       _____

    From: owner-seafood@ucdavis.edu [mailto:owner-seafood@ucdavis.edu] On Behalf
    Of Hungerford, James M
    Sent: 31 January 2005 19:40
    To: 'seafood@ucdavis.edu'
    Subject: Histamine Field Test

     

    A question for those in the seafood industry, government regulators,
    inspectors, analysts, etc:

    How many of you would purchase and use a simple and rapid field test for
    histamine in fresh, frozen, or canned fish?

    I am exploring the possiblities for a commercially available field test kit
    for histamine that would use a simple cassette format (lateral flow cassette
    as used in pregnancy test kits). There would be no chemicals to handle, and
    no solutions other than the distilled-water extract of fish (prepared on
    site) since the test kit itself is "solid state." The kit would respond in
    approx 30 min. Sample requirements are low and their is potential for less
    "disfigurement" of the fish as discussed on this forum. Results would be
    qualitative (for example "above 50 PPM" or "below 50 PPM") and would mainly
    be used for screening and for quality control.

    Roughly how many tests would your firm or agency perform each year?

    What do you feel is a reasonable cost per sample?
    Please note that although I work for FDA, statements made in this message do
    not reflect FDA policy.

    Please respond with your thoughts on this.

    Thank You for your time.

    Sincerely,

    James Hungerford, Ph.D.
    Chair of AOAC Task Force and GR, Marine and Freshwater Toxins,

    Research Chemist
    FDA Seafood Products Research Center
    22201 23rd Dr SE
    Bothell, WA 98021
    USA
    Phone 425-483-4894
    FAX 425-483-4996

    James.Hungerford@fda.gov

     

     

    Message from Walter Staruszkiewicz in November 2004

     

    "Consumer illness from the ingestion of decomposed and scombrotoxic fish
    remains a major public health problem. Most of the unsafe fish are received
    as imported products. There has been a long standing problem of inadequate
    attention given to preventing bacterial decomposition at the point of
    harvest which results in the production of irreversible unsafe chemical
    changes in fish.

     

    "The progression of bacterial decomposition which leads to the formation of
    histamine and other biogenic amines begins in the anterior end of a fish and
    the highest concentrations of the amines are usually found in the lower
    anterior region. These changes are not always accompanied by obvious odors
    of decomposition within the muscle. It is necessary to sample the tissue at
    the anterior end cutting through the transverse section (backbone to belly)
    to have a high degree of reliability in assessing the safety of the fish.
    The sample location rather than the amount of tissue is the important
    factor. Our publication in the January

    2004 issue of the J of Food Protection* documents the rapid formation of
    biogenic amines in susceptible fish.

     

    "The reality is that fish are harvested, delivered, transported and offered
    for sale in the U.S. that contain high concentrations of histamine due to
    bacterial decomposition. These shipments of fish usually consist of a
    mixture of very good quality fish commingled with decomposed and unsafe
    fish. They may be accompanied by "certificates" alleging an absence of
    histamine or decomposition. Our laboratories have identified scombrotoxic
    levels of histamine in such shipments and we have had numerous reports of
    consumer illness from scombrotoxic fish delivered at the retail level.

     

    "Until a valid control mechanism is established from the point of harvest at
    sea through the delivery of fish, chemical analysis will remain the only
    reliable test of safety for scombroid-type fish. "Certificates" and good
    intentions will not suffice as substitutes."

     

    Walter Staruszkiewicz

    Research Chemist

    FDA

    Laurel, MD

     

     

     

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