[Fwd: PRO> ProMED Digest V2004 #232]

From: Liz Brown (bfeab@uaf.edu)
Date: Tue Jun 22 2004 - 10:28:41 PDT

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    Date: Mon, 21 Jun 2004 21:03:24 -0400 (EDT)
    From: ProMED-mail <promed@promed.isid.harvard.edu>
    Subject: PRO/AH/EDR> Food poisoning, octopus, fatal - Viet Nam

    FOOD POISONING, OCTOPUS, FATAL - VIET NAM
    **********************************
    A ProMED-mail post
    http://www.promedmail.org
    ProMED-mail, a program of the
    International Society for Infectious Diseases
    http://www.isid.org

    [1]
    Date: 21 Jun 2004
    From: Alfonso Rodriguez <arodriguezm@SaludFMV.org>
    Source: Yahoo News, UK [edited]
    <http://uk.news.yahoo.com/040621/323/ewc3a.html>

    Poisonous octopus leaves 2 dead, 85 hospitalized in Viet Nam
    - --------------------------
    2 people died and 85 others, including 42 children, needed hospital
    treatment after eating poisonous octopus in a village in southern Viet Nam,
    health officials said.

    A man and a woman in Binh Thuan province's Tam Ngan village died on
    Saturday after eating the blue-ringed octopus, while other villagers were
    rushed to hospital, said a provincial health official.

    They all bought the blue-ringed octopus, a very small organism with
    poisonous glands, from the village market.

    - --
    ProMED-mail
    <promed@promedmail.org>

    ******
    [2]
    Date: 21 Jun 200r
    From: Alfonso Rodriguez <arodriguezm@SaludFMV.org>
    Source: Xinhuanet News, China [edited]
    <http://news.xinhuanet.com/english/2004-06/21/content_1538295.htm>

    3 Vietnamese die from poisonous octopus
    - ------------
    3 people in southern Vietnamese province of Binh Thuan died, and 85 others
    - -- including 42 children -- were hospitalized after eating blue-ringed
    octopus on Saturday. Of the fatalities, 1 died on the way to the hospital
    and 2 others at the hospital, according to local newspaper Labor on Monday.

    This is the biggest poisoning case regarding blue-ringed octopuses in the
    province. All of the victims showed symptoms of headache and numbness in
    arms and legs.

    A 25-gram blue-ringed octopus, whose scientific name is _Hapalochlaena
    maculosa_, can claim 10 human lives, because it has a strong toxin known as
    Tetrodotoxin.

    - --
    ProMED-mail
    <promed@promedmail.org

    [Tetrodotoxin (anhydrotetrodotoxin 4-epitetrodotoxin, tetrodonic acid) may
    also be known as Pufferfish Poisoning, Tetradon Poisoning, and Fugu Poisoning

    Poisoning by members of the order Tetraodotiformes is perhaps one of the
    most violent -- if not the worst -- intoxication from marine species.
    Tetrodotoxin is found in the gonads, liver, intestines, and skin of the
    pufferfish. The toxin levels in these locations are sufficient to produce
    rapid and violent death. Usually the flesh or the meat of the fish is not
    toxic, provided it was not contaminated with the toxin from its own organs
    during the preparation of the fish.

    Tetrodotoxin has been isolated from a wide array of animal species,
    including the blue-ringed octopus, starfish, parrotfish, California newt,
    frogs of the genus _Atelopus_, the angelfish, and xanthid crabs.

    Until recently tetrodotoxin was believed to be a metabolic product of
    unspecified source within the host. No algal source had been identified.
    However, recent reports of the production of
    tetrodotoxin/anhydrotetrodotoxin by several bacterial species, including
    strains of the family _Vibrionaceae_, _Pseudomonas_ sp., and
    _Photobacterium phosphoreum_, point toward a bacterial origin for this
    family of toxins. These are relatively common marine bacteria that are
    often associated with marine animals. If confirmed, these findings may have
    some significance in toxicoses that have been more directly related to
    these bacterial species.

    The 1st signs of intoxication include a slight numbness of the lips and
    tongue, usually becoming evident between 20 minutes to 3 hours after
    consumption of the poison. The next symptom is increasing paresthesia in
    the face and extremities, which may be followed by sensations of lightness
    or floating. Headache, epigastric pain, nausea, diarrhea, and/or vomiting
    may occur. Occasionally, some reeling or difficulty in walking may also be
    noted.

    The 2nd stage of the intoxication is increasing paralysis. Many victims are
    unable to move; even sitting may be difficult. Respiratory distress
    increases and, as dyspnea increases, the speech is affected. The victim
    usually exhibits cyanosis and hypotension. Paralysis increases and
    convulsions, mental impairment, and cardiac arrhythmia may follow. The
    victim, although completely paralyzed, may be conscious and in some cases
    completely lucid until shortly before death. Death usually occurs within 4
    to 6 hours, with a known range of about 20 minutes to 8 hours.

    Supportive care is helpful, but may be of limited effect. - Mod.TG]

    -- 
    Liz Brown
    Marine Advisory Program
    University of Alaska Fairbanks
    PO Box 1549
    Dillingham, AK 99576
    907-842-1265
    Fax 907-842-3202
    



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