FDA Seeks Industry Input in Determining Appropriate Revisions to the Curreng GMPs.

From: Pamela Tom (pdtom@ucdavis.edu)
Date: Sun May 23 2004 - 20:02:46 PDT

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    The Food and Drug Administration (FDA) will conduct three public meetings
    to solicit comments, data, and scientific information about the current
    state of quality management techniques, quality systems approaches, and
    voluntary industry standards concerning current good manufacturing
    practices and other controls used by food manufacturers and processors to
    prevent, reduce, control, or eliminate food borne hazards that can occur
    during food production or processing. The meetings are intended to elicit
    information about FDA's current good manufacturing practice (CGMP) in
    manufacturing, packing, or holding human food regulations. This
    information will be useful in determining appropriate revisions to these
    regulations.

    FDA is particularly interested in receiving comments about food
    manufacturing practices and other controls used by small food
    manufacturing and processing entities.

    FDA asks that those who speak at the meetings or otherwise provide FDA
    with their comments focus on questions given in section II of the Federal
    Register (May 21, 2004 Vol. 69, No. 99, Pages 29220-29222) about the CGMP
    regulations and other quality management techniques. There also will be
    an opportunity to address small business concerns at the meetings.

    DATE AND LOCATIONS OF THE PUBLIC MEETINGS:

    Friday, June 11, 2004 - Food and Drug Administration, Center for Food
    Safety and Applied Nutrition, 5100 Paint Branch Pkwy., College Park, MD
    20740-3835.

    Friday, July 2, 2004 - Monterey Conference Center, One Portola Plaza,
    Monterey, CA 93940.

    Wednesday, July 21, 2004 - Marriott Chicago Downtown, 540 North Michigan
    Ave., Chicago, IL 60611.

    II. QUESTIONS THAT THE FDA IS SEEKING ANSWERS FROM INDUSTRY ON:

        In general, do the current good manufacturing regulations (part 110)
    need to be revised or otherwise modernized? If yes, please describe
    generally the shortcomings of the current regulations.

        1. Which practices specified in current part 110 are most effective at
    preventing each type of food hazard? Which practices are least effective
    at such prevention?
        2. In today's food manufacturing environment, what conditions,
    practices, or other factors are the principal contributors to each type of
    food hazard?
        3. If the CGMP regulations were revised, which type or types of food
    hazards could be most readily prevented through CGMP-type controls?
        4. Are there preventive controls, in addition to those set out in part
    110, needed to reduce, control, or eliminate each of the three types of
    food hazards? If yes, please identify the specific hazard and the
    particular controls, that would reduce, control, or eliminate the hazard.
        5. What concepts or underlying principles should guide FDA's adoption
    of new preventive controls?
        6. How should the effectiveness of preventive controls for each of the
    three types of hazards be most accurately measured?
        7. In today's food manufacturing environment, what are the principal
    contributors to the presence of undeclared allergens in food? For
    example, do labeling errors or cross-contamination contribute? Which
    preventive controls could help reduce, control, or eliminate the presence
    of undeclared allergens in food?
        8. Are there existing quality systems or standards (such as
    international standards) that FDA should consider as part of the agency's
    exploration of food CGMP modernization? Please identify these systems or
    standards and explain what their consideration might contribute to this
    effort.
        9. There is a broad variation within the food manufacturing and
    processing industry, including variations in size of establishments, the
    nature of the food produced, the degree to which the food is processed,
    and the vulnerability of a particular operation to physical, chemical, or
    microbial hazards. How, if at all, should the CGMP regulations be revised
    to take into account such variation? For example, should there be
    different sets of preventive controls for identifiable segments of the
    food industry, such as different storage temperature limits?
        10. There are a number of measures, procedures, and programs that help
    to ensure that preventive controls are carried out adequately. These
    include the following items:
        - Training programs for managers and/or workers;
        - Audit programs;
        - Written records, e.g., batch records, sanitation records;
        - Validation of control measures;
        - Written sanitation standard operating procedures;
        - Food label review and control program; and
        - Testing of incoming raw materials, inprocess materials, or
          finished products.
    Which (if any) of these should be required practices for food and
    manufacturers and why? Which (if any) of these should be recommended
    practices for food manufacturers and processors and why?
        11. Are there preventive controls in addition to those already set out
    in part 110 for food distributors, wholesalers, and warehousers that are
    needed to help ensure the safe and sanitary holding of food? If yes,
    please identify the controls by hazard and sector of the industry.

    FOR MORE INFORMATION:
    Information on how to register to attend the meetings, and
    how to submit comments electronically are in the Federal Register on the
    web at: http://www.cfsan.fda.gov/~lrd/fr040521.html

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