RE: Student needing help!!!

From: Lupin, Hector (FIIU) (Hector.Lupin@fao.org)
Date: Mon Feb 17 2003 - 01:52:32 PST

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    Dear Grey,
     
    Many years ago I was involved in a similar problem. Old regulations did not
    recognized that TVB-N in canned fish would be higher than the TVB-N content
    of the raw material, because they did not have into account the thermal
    decomposition of TMAO. This in the past was a common reason for rejection of
    canned fish (high TVB-N). We published a research note on this:
     
    Production of nitrogen volatile basis on fish during the canning process
    Yeannes, M.I.; del Valle C.E. and Lupin, H.M.
    Rev. Agroquim. Tecnol. Alim., 23(4), pp 585-590, 1983 (Spain) (20 years, my
    God!!)
     
    (the paper is in Spanish with a short abstract in English)
     
    Eventually regulations changed in the sense that TVB-N was not taken any
    longer as a reliable uality/safety index for canned fish.
     
    We did not measure TMAO, because this was not of regulatory interest,
    however, we noticed that the strong (time/T) the treatment the large the
    production of TVB-N (we included this observation in the paper).
     
    I remember that one of the observations from people in regulatory bodies to
    this paper was that we had not identified a "final" value for TVB-N for the
    cooking/ sterilization process (there is a reduction of TMAO also during
    cooking before sterilization). Of course this would depend of the initial
    content of TMAO, that is different in each specie and has variations within
    the same specie, we answered.
     
    Nevertheless, we performed some experiments cooking and retorting till to
    get a plateau in the TVB-N (which could indicate a total depletion of TMAO),
    but for the species we worked with, this plateau corresponded to t/T stories
    that were well above the commercial ones for commercial sterilization. We
    never published such a result, but from that I would be tempted to suggest,
    that in (at least some) commercial canned fish, there is still some
    remaining TMAO. You could replicate this experiment very easily for your
    conditions.
     
    Kind regards.
     
    Hector M. Lupin
    Senior Fishery Industry Officer (Quality Assurance)
    Fish Utilization and Marketing Service (FIIU)
    Fishery Industries Division (FI)
    Fisheries Department, FAO, Room F 606
    Viale delle Terme di Caracalla 00100 Rome Italy
    Tel + 39 06 570 56459
    Fax + 39 06 570 55188
    E-mail: hector.lupin@fao.org

     
     
     
     
     

    -----Original Message-----
    From: Peter Howgate [mailto:phowgate@rsc.co.uk]
    Sent: 07 February 2003 23:57
    To: D. Grey Allen; seafood@ucdavis.edu
    Subject: Re: Student needing help!!!

    Dear Grey

    A paper I have, (there might be others), on the topic of breakdown of TMAO
    during canning is:

    Hughes, R.B., 1963, Some effects of heat_processing on herring. In: Food
    Science & Technology, Proceedings of the first International Congress of
    Food Science and Technology, London, September 18-21, 1962, Volume III,
    Quality, Analysis and Composition, J.M. Leitch, ed, Gordon and Breach
    Science Publishers, pp 477-489.

    In it Hughes writes:

    "Trimethylamine oxide in herring is reduced during heat_processing (Ronold
    and Jakobsen, 1947), but it was further established (Hughes, 1959) that
    dimethylamine as well as trimethylamine is a major breakdown product, being
    formed in the approximate proportion of 1 mole of dimethylamine to 2 moles
    of trimethylamine. This suggested that trimethylamine oxide is decomposed in
    two ways, namely: (CH3)3NO to (CH3)N + O, and to (CH3)2NH + HCHO. Both these
    reactions proceed when trimethylamine oxide is heated in the presence of
    reducing agents (Dunstan and Goulding. 1899), and Vaisey (1956) recently
    demonstrated that the oxide is reduced by both the above pathways even at
    room temperature, in the presence of naturally_occurring reducing agents.
    Ota (1958) has confirmed this by showing that the thermal breakdown of
    trimethylamine oxide is accelerated by certain amino acids such as cysteine,
    while Hattori and Hasehe (1934) had previously demonstrated the production
    of both dimethylamine and formaldehyde in heated squid extracts."

    The citations are:

    Dunstan W. R., and Goulding, E., J. Chem. Soc. (7.) 75, 792 (1899)

    Hughes, R. B., J. Sci. Food Agric. 10, 431 (1959).

    Ronold O.A. and Jakobsen F., J Soc Chem. Ind., 66. 160 (1947).

    Vaisey, E.B., Canadian J. Biochem. Physiol., 34, 1085 (1956).

    The paper has a figure showing production of TMA and DMA over 5 hours of
    heating herring at 120ºC which comes from the Hughes (1959) paper, but I do
    not have a copy of this.

    The phenomenon of 'greening' in canned tuna is related to the TMAO content
    of the raw tuna. The papers on this topic that I have give values for the
    TMAO content of raw tuna, but not of the canned product.

    It might be worth following up the Hughes papers in Science Citations Index
    for papers citing them, and also ASFA and/or FSTA for relevant publications.

    You can always check on TMAO loss in your products as it is easy to measure
    TMAO if you are going to measure volatile bases. Measure the bases in an
    extract before and after reduction with titanous chloride.

    Peter Howgate

    _____ Original Message _____

    From: D. Grey Allen

    To: seafood@ucdavis.edu

    Sent: Wednesday, February 05, 2003 10:59 PM

    Subject: Student needing help!!!

    I am a student at NC State University, and I am looking into inoculating a
    sterilized (autoclaved) fish tissue based media (either tuna and/or
    mahi_mahi) with bacterial isolates and determining the rate they produce
    volatile basic nitrogens. My question is, would there be enough TMAO and
    other substrates left, after autoclaving, to interact with bacterial enzymes
    to produce volatile basic nitrogens. Any references that illustrate the
    answer to this question would be appreciated.

    Thank you,

    D. Grey Allen

    ----- Original Message -----
    From: D. <mailto:dgallen2@unity.ncsu.edu> Grey Allen
    To: seafood@ucdavis.edu <mailto:seafood@ucdavis.edu>
    Sent: Wednesday, February 05, 2003 10:59 PM
    Subject: Student needing help!!!

    I am a student at NC State University, and I am looking into inoculating a
    sterilized (autoclaved) fish tissue based media (either tuna and/or
    mahi-mahi) with bacterial isolates and determining the rate they produce
    volatile basic nitrogens. My question is, would there be enough TMAO and
    other substrates left, after autoclaving, to interact with bacterial enzymes
    to produce volatile basic nitrogens. Any references that illustrate the
    answer to this question would be appreciated.

    Thank you,
    D. Grey Allen



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